About 7% of people with parkinsonism have developed their symptoms following treatment with particular medications. This form of parkinsonism is called ‘drug-induced parkinsonism’. Drug induced etiology must always be suspected when parkinsonian symptoms appear or increase in a patient receiving drug treatment. Domperidone is commonly prescribed in the treatment of vomiting and gastroesophageal reflux but its side effects are rarely seen. They usually occur in infants and very young children due to a poorly developed blood–brain barrier. Contrary to the initial expectations, domperidone is able to penetrate into the hematoencephalic barrier and to cause neurological adverse reactions. We reported a case of drug-induced parkinsonism reaction in a 59 year old female patient who was treated with domperidone 10 mg tablets twice a day through oral route for a period of one year.
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